ICMJE Requirements

ICMJE Registration Requirements
International Committee for Medical Journal Editors  
What is ICMJE?
The ICMJE is a group of general medical journal editors that include:

  • New England Journal of Medicine
  • Journal of the American Medical Association
  • Annals of Internal Medicine
  • The Lancet
  • The Medical Journal of Australia
  • The New Zealand Medical Journal
  • Norwegian Medical Journal
  • Canadian Medical Association Journal
  • Croatian Medical Journal
  • Dutch Journal of Medicine
  • Journal of the Danish Medical Association

What are the ICMJE requirements for clinical trials registration?
The ICMJE member journals will require, as a condition of consideration for publication in their journals, registration in a public trials registry.

The ICMJE defines a clinical trial as any research project that prospectively assigns human subjects to intervention or concurrent comparison or control groups to study the cause-and-effect relationship between a medical intervention and a health outcome. Medical interventions include drugs, surgical procedures, devices, behavioral treatments, process-of-care changes, and the like.
More information can be found at:

ICMJE Obligation to Register Clinical Trials 

ICMJE FAQ 

When do I register?
Registration must be completed:

  • Prior to enrollment of 1st subject, AND
  • Updated at least every 6 months